Sergel 20 mg
- Generic Name: Esomeprazole
- Manufacturing Company: Healthcare Pharmaceuticals Limited
The price Sergel 20
- Per piece: 7 Tk
- Strip: 70 Tk (10 tablets)
- Box: 700 Tk (10*10 Tablets)
Sargel, a proton pump inhibitor (PPI) capsule, comes in a dosage of 20 mg and is used to treat gastro-oesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome (ZES). It relieves the disease by reducing stomach acid production. The best time to take Sergel is one hour before meals. It is a generally safe drug with mild side effects and interactions with some medications. Pregnant or lactating women should consult a doctor before consumption.
Alternative medicine to Sergel 20
| SL | Alternative | Company | Price (per piece) |
| 1 | Maxpro 20 | Renata Limited | 7 Tk |
| 2 | Exium | Radiant Pharmaceuticals | 8.50 Tk |
| 3 | Nexum | Square Pharmaceuticals | 7 Tk |
| 4 | Esoral 20 | Eskayef Bangladesh Ltd | 7 Tk |
| 5 | Opton | Beximco Pharmaceuticals Ltd. | 7 Tk |
Idications | Sergel 20 mg
Use Sargel 20 mg in the following cases. Doctors recommend using capsules in the following situations:
- To relieve symptoms of gastro-oesophageal reflux disease (GERD).
- Erosive oesophagitis helps to heal wounds in the lining of the oesophagus.
- Sargel 20 combines with amoxicillin and clarithromycin to help kill bacteria and heal ulcers.
- Sargel 20 keeps gas problems under control by reducing acid production.
note: Before taking any medicine, consult your doctor.
Pharmacology
Esomeprazole is a proton pump inhibitor medication. It reduces stomach acid production by inhibiting a specific enzyme called H+/K+-ATPase in the gastric parietal cells of the stomach. It’s important to note that esomeprazole is the S-isomer of omeprazole, which is a single optical isomer. It controls stomach acid levels better than racemic proton pump inhibitors.
Dosage and Administration | Sergel 20 mg
Esomeprazole is available in two forms: oral capsule and intravenous injection. The dosage details for oral and intravenous esomeprazole are below:
Oral Dosage:
- Treatment of Erosive Oesophagitis:
- 20 mg or 40 mg, once daily, 4-8 weeks.
- Patients usually recover within 4-8 weeks. If not cured in 4-8 weeks may continue for another 4-8 weeks.
- Maintenance of normal status: 20 mg, once daily (clinical studies did not last more than 6 months).
- To relieve symptoms of gastric reflux esophagitis (GERD):
- 20 mg, once daily, 4 weeks.
- If the symptoms persist after 4 weeks, you may consider another 4 weeks of treatment.
- Eradication of Helicobacter pylori:
- Triple therapy to reduce the risk of duodenal ulcer recurrence—esomiprazole 40 mg, once daily, 10 days; Clarithromycin 500 mg, twice daily, 10 days.
- Zollinger-Ellison syndrome:
- 20-80 mg, once daily. Dosage should be individualised, and treatment continued as medically necessary.
- Acid related dyspepsia:
- 20-40 mg, once daily, 2-4 weeks, depending on response.
- Duodenal ulcer:
- 20 mg, once daily, 2-4 weeks.
- Gastric ulcer:
- 20-40 mg, once daily, 4-8 weeks.
IV injection or infusion:
- Gastric reflux ooesophagitis (GERD) with erosive ooesophagitis:
- Adult patients (≥18 years): 20 mg or 40 mg, once daily.
- Pediatric patients (1 year to 17 years):
The intravenous dose of esomeprazole depends on the child’s weight:
- Body weight <5 kg:
- 10 mg, once daily.
- Body weight 5-10 kg:
- 15 mg, once daily.
- Body weight 10-15 kg:
- 20 mg, once daily.
- Body weight 15-20 kg:
- 25 mg, once daily.
Note that you should always consult your doctor for the correct dosage and dosage.
Drug interactions
Two liver enzymes, CYP2C19 and CYP3A4, primarily activate Sergel. Studies have shown that Sergel does not usually interfere with the effectiveness of many other medications. Notably, any Sergel complexation with drugs metabolised by CYP 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4 enzyme interaction (drug interaction) is less likely to occur. Studies have also shown that Sergel has no serious interactions with drugs such as phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin.
Although Sergel is generally compatible with many medications, problems may occur in some cases. Sergel may inhibit the CYP2C19 enzyme’s activity. This enzyme mainly metabolises the drug Sergel. For instance, the CYP2C19 enzyme metabolises the drug diazepam. Combine Sergel (30 mg) with diazepam. This action could potentially slow down the body’s elimination of diazepam, leading to a rise in its blood levels.
Side Effects | Sergel 20 mg
Sergel 20 mg (esomeprazole) is generally well tolerated by everyone, but some side effects may occur in some.
- headache
- diarrhoea
- nausea
- flatulence
- Abdominal pain
- Constipation
- dry mouth
Important points: If any serious side effects occur, contact your doctor immediately.
Use during pregnancy and lactation
Consumption during pregnancy:
- There is not enough information about Sergel 20’s risk to pregnant women.
- Animal studies have not shown birth defects.
Consumption during lactation:
- There is not enough information about Sergel 20’s risk to breast-feeding women.
- If breastfeeding women need to use Sargel 20, they should stop breastfeeding or consult their doctor about changing the medication.
Guidance
People who are allergic to esomeprazole or any of its ingredients should not take Sergel 20 mg.
Overdose effects
A single oral dose of Sergel at 510 mg/kg (about 103 times the human dose on a body surface area basis), has been lethal to rats. The major signs of acute toxicity are reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions. There have been no reports of overdose with Sergel. No specific antidote for Sergel is known. Since Sergel is extensively protein bound, it is not expected to be removed by dialysis. In the event of overdosage, treatment should be symptomatic and supportive. As with the management of any overdose, the possibility of multiple drug ingestion should be considered.
Therapeutic classes
Therapeutic classes are: Proton Pump Inhibitors (PPIs)
Warning | Sergel 20 mg
Sargel 20 can be mixed with applesauce if there is a problem in swallowing. However, if you are pregnant or lactating, have kidney or liver problems, or are taking other medications, do not consume them without consulting a doctor. There may be side effects, especially headaches, diarrhoea, etc.
Chemical Composition
Chemical signals: C17H19N3O3S
Chemical composition:
Storage Conditions
Store in a cool, dry place away from light and moisture, and keep out of reach of children.
***Special announcement
We have carefully gathered the information from various sources, but it should not be used as a substitute for medical advice. Always consult a doctor before using any medication. We cannot guarantee the effectiveness and usefulness of the information we collect from various sources. Therefore, we are not responsible for any side effects or side effects after taking the medicine due to the information mentioned above.
- This information is for general information only and is in no way a substitute for medical advice.
- Sergel 20 mg Before taking tablets, consult your doctor.
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Sergel 20 | Frequently Asked Questions – FAQ
What is Sargel 20?
Sergel 20 is a proton pump inhibitor (PPI) medication. The active ingredient in Sergel 20 is esomeprazole.
How does Sargel 20 work?
Sargel 20 works by reducing stomach acid. It blocks the H+/K+ ATPase pump of parietal cells, thereby reducing acid production.
What are the uses of Sargel 20?
Sargel 20 is used to treat the following conditions:
- Gastro-oesophageal Reflux Disease (GERD) Treatment.
- Stomach ulcer treatment.
- Zollinger-Ellison syndrome treatment.
What is the dose of Sargel 20?
The dose of Sergel 20 mg depends on your age, weight, and medical condition. Usually, the dose is once daily.
Sergel 20 mg: What is the recommended frequency of consumption?
The duration of Sergel 20 mg intake depends on your medical condition. Your doctor should advise you on how to consume the medicine.
What are the side effects of Sargel 20?
The following are common side effects of Sergel 20 mg:
- headache
- diarrhoea
- Abdominal pain
- nausea
- Constipation
- dizziness
Is Sargel 20 safe for pregnant or lactating mothers?
If you’re pregnant or breastfeeding, talk to your doctor before taking Sergel 20 mg.
When shouldn’t the use of Sergel 20 mg cease?
If you are allergic to esomeprazole or any other PPI medication, you should not use Sergel 20 mg .
What is the price for Sargel 20?
The price of Sargel 20 depends on the brand and company, it is usually around 7 to 8 Tk.
How long to take Sargel 20?
The duration of your Sergel 20 mg treatment is entirely dependent on your specific disease. Your doctor is your disease condition and nature according to determining the duration of treatment.
Will taking Sargel 20 along with my other medications cause problems?
Taking Sargel 20 together with some medicines can cause problems. This topic is covered in detail in the upper sections of this blog.
reference
- Company: https://www.hplbd.com/product-details.php?pid=122
- USP: https://store.usp.org/amino-acids/category/USP-1901?_gl=1*73hjs
- Generic: https://bn.wikipedia.org/wiki/%E0%A6%87%E0%A6%B8%E0%A7%8B%E0%A6%AE%E
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