thyrin 50 mg. Tablets || Price, Generic, Dosage, and all information 

• Generic name:  Levothyroxine Sodium 
• Manufacturing Company:  Square Pharmaceuticals Ltd.

The price of thyrin 50 mg  

• Per piece: 2.25 Tk
• Strip: 33.75Tk (15 tablets)
• Box: 202.50Tk (15*6 tablets)

Levothyroxine, or T4, is a synthetic thyroid hormone primarily used to treat hypothyroidism, ensuring the body receives adequate hormone levels for normal thyroid function. It is crucial to avoid its use during the recovery phase of transient hypothyroidism related to subacute thyroiditis. Beyond treating hypothyroidism, Levothyroxine also suppresses Thyroid Stimulating Hormone (TSH) levels in conditions like goitres and post-thyroid cancer treatment. Its pharmacological action involves converting a portion of T4 to the more active Triiodothyronine (T3), maintaining stable blood levels with a single daily dose due to its long half-life. Dosing is tailored to individual patient needs, considering factors like age and existing medical conditions. With careful monitoring and adherence to guidelines, Levothyroxine can significantly enhance the quality of life for those affected by thyroid disorders.

Alternative medicine 

There are many alternatives to thyrin 50 mg from different companies in the market; they are:  

Sl:	alternative	company	Price
1.	Thyrox 50 mg	Renata Limited	2.20 Tk
2.	Thyronor 50mg	Nuvista Pharma Limited.	2 Tk
3.	Thyrolar 50mg	ACME Laboratories Ltd.	3 Tk
4.	Synroid 50mg	Beximco Pharmaceuticals Ltd.	1.60 Tk
5.	Thynor 50 mg	Eskayef Bangladesh Ltd	2 Tk

Indications | thyrin 50 mg

thyrin 50 mg, containing synthetic Levothyroxine, is indicated for the following:

1. Hypothyroidism: Used as replacement therapy for hypothyroidism of any etiology, except during the transient phase of subacute thyroiditis.
2. TSH Suppression: To suppress Thyroid Stimulating Hormone (TSH) levels in patients with goitres, thyroid nodules, or after treatment for thyroid cancer.
3. Goitrogenic Effects: To counteract the goitrogenic effects of certain medications, such as Lithium.
4. Diagnostic Aid: As a diagnostic tool in suppression tests to assess thyroid function.

Always consult a registered physician before use.

Pharmacology thyrin 50 mg

 This tablet contains synthetic Levothyroxine (commonly known as Thyroxine or T4), which is identical to the natural hormone produced by the thyroid gland. Approximately 30% of T4 is converted into the more active Triiodothyronine (T3) in peripheral tissues. Thyroxine Binding Globulin (TBG) serves as the primary carrier for T4, protecting it from metabolism and excretion, which contributes to its long half-life in the bloodstream. Only about 0.03% of total T4 in plasma remains unbound. The elimination half-life of T4 is typically 6 to 7 days; however, in hyperthyroidism, this is reduced to 3 or 4 days, while in hypothyroidism, it may extend to 9 to 10 days. Conditions like nephrosis or hepatic cirrhosis can also shorten T4’s half-life due to reduced plasma proteins. The liver is the primary site for thyroid hormone degradation. T4 is conjugated with glucuronic and sulfate compounds via the phenolic hydroxyl group and excreted in urine. Additionally, there is an enterohepatic circulation of thyroid hormones, as they are released through hydrolysis in the intestine and reabsorbed. Thanks to T4’s long half-life, a steady level of the more active T3 can be achieved with a single daily dose of Levothyroxine, minimizing variations in therapeutic effects once the correct dosage is determined.

Dosage and Administration  

Adult Dose:

• Initial Starting Dose: 25-50 mcg/day. Gradual increments of 12.5-25 mcg should be made at 6-8 week intervals, as necessary. Adjust the dose until the patient with primary hypothyroidism is clinically euthyroid and serum TSH levels normalize.
• Severe Hypothyroidism: Start with 12.5-25 mcg/day and increase by 25 mcg/day every 2-4 weeks, monitoring clinical and laboratory parameters until TSH levels normalize.
• Secondary or Tertiary Hypothyroidism: Titrate the Levothyroxine dose to achieve clinical euthyroidism and restore serum free T4 to the upper half of the normal range.
• Older Adults or Patients with Cardiac Disease: 1.7 mcg/kg/day.

Pediatric Dosage:

• Newborns: Starting dose is 10-15 mcg/kg/day, with adjustments based on clinical response. For infants with very low serum T4 levels (<5 mcg/dL), start with 50 mcg/day.
• Infants and Children: Initial dose of 25 mcg/day, increasing by 25 mcg every 2-4 weeks. Adjust based on response.
  • 0-3 months: 10-15 mcg/kg/day
  • 3-6 months: 8-10 mcg/kg/day
  • 6-12 months: 6-8 mcg/kg/day
  • 1-5 years: 5-6 mcg/kg/day
  • 6-12 years: 4-5 mcg/kg/day
  • >12 years (incomplete growth/puberty): 2-3 mcg/kg/day
  • Complete growth/puberty: 1.7 mcg/kg/day

Note: Dosages should be adjusted based on clinical response and laboratory parameters. Always consult with a registered healthcare professional before starting or adjusting medication. 

Drug interactions

The concurrent use of tri/tetracyclic antidepressants with Thyrin may enhance the therapeutic and toxic effects of both medications, potentially due to increased receptor sensitivity to catecholamines. This can lead to a higher risk of cardiac arrhythmias and central nervous system stimulation, with a quicker onset of action for tricyclics.

Additionally, administering sertraline to patients who are stabilized on Thyrin may result in a higher requirement for Thyrin. Combining Thyrin with antidiabetic medications or insulin may increase the dosage needed for effective glycemic control. Therefore, careful monitoring of blood sugar levels is essential when initiating, adjusting, or discontinuing thyroid therapy.

Moreover, in hyperthyroid patients or those transitioning to a euthyroid state, serum levels of digitalis glycosides may decrease, which can diminish the therapeutic effect of these medications. 

Side effects  

The side effects associated with Thyrin therapy are primarily linked to hyperthyroidism, often resulting from an overdose. These may include:

• General Symptoms: Fatigue, increased appetite, weight loss, heat intolerance, fever, and excessive sweating.
• Central Nervous System: Headaches, hyperactivity, nervousness, anxiety, irritability, emotional lability, and insomnia.
• Musculoskeletal: Tremors and muscle weakness.
• Cardiovascular: Palpitations, tachycardia, arrhythmias, and elevated blood pressure.
• Respiratory: Shortness of breath (dyspnea).
• Gastrointestinal: Diarrhea, vomiting, and abdominal cramps.
• Dermatological: Hair loss and flushing.

It’s important to monitor for these side effects, especially if there are signs of overdose or hyperthyroidism. 

Use during pregnancy and lactation 

 Thyrin is classified as a Pregnancy Category A medication, indicating that it is generally considered safe for use during pregnancy. However, pregnant women may have increased requirements for Levothyroxine, necessitating careful monitoring and possible dosage adjustments to maintain proper thyroid function.

Although Thyroid hormones are minimally excreted in human milk, caution is advised when administering Thyrin to nursing mothers. Adequate replacement doses of Levothyroxine are typically needed to support normal lactation. It is essential to consult a healthcare provider for appropriate dosing and monitoring during pregnancy and lactation to ensure the well-being of both the mother and the infant.

Guidance 

• Consult a Doctor: Use under medical supervision.
• Monitor Levels: Regularly check TSH and T4.
• Start Low: Use caution in patients with heart issues.
• Report Interactions: Inform about all medications.
• Adjust for Weight: Change dosage with significant weight changes.
• Watch for Side Effects: Report symptoms of hyperthyroidism.
• Pregnancy/Breastfeeding: Consult your doctor for dosage adjustments.

Follow these steps for safe Thyrin use. 

Effects of overdose

Overdosing on Thyrin can result in various symptoms associated with hyperthyroidism. Individuals may experience agitation, confusion, and hyperactivity, leading to increased nervousness and cognitive disorientation. Other common symptoms include headaches and excessive sweating, alongside tachycardia, which is a rapid heartbeat that can lead to arrhythmias. Patients may also notice an increased frequency of bowel movements and fever. Mydriasis, or dilated pupils, may occur, and in severe cases, convulsions can happen. Serious complications such as shock, cerebral embolism, coma, or even death have been reported. If any signs of overdose are evident, it is crucial to reduce or discontinue Thyrin immediately and seek medical attention. 

Therapeutic classes 

Therapeutic classes are: Thyroid drugs & hormone

Warning | thyrin 50 mg   

Cautions for Thirin 50 Consumption:

• Pituitary Gland Disorders: Use with caution.
• Heart problems: Use caution in dosing.
• Weight gain: Time the levels.
• Blood tests: Monitor T3, T4 and TSH levels.
• Overdose: May cause serious problems.

Chemical composition

Chemical Formula: C15H11I4NO4

Chemical Stucture: 

Storage Conditions 

 

***Special announcement

Although we have carefully gathered the information from various sources, you should not use it as a substitute for medical advice. Always consult a doctor before using any medication. Our source-based information cannot be guaranteed to be effective or useful. Therefore, we cannot be held responsible for any side effects that may occur after taking the medicine, due to the information mentioned above.

• This information is for general information only and is in no way a substitute for medical advice.

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Thyrin 50 Mg: FAQs  

What is Thyrin used for? 

Thyrin is primarily used for the replacement therapy in hypothyroidism and to suppress Thyroid Stimulating Hormone (TSH) levels in goiters and thyroid cancer cases.

What are the active ingredients in Thyrin? 

Thyrin contains synthetic Levothyroxine, also known as Thyroxine or T4, which is identical to the natural hormone produced by the thyroid gland.

How does Thyrin work in the body? 

Thyrin works by replacing the deficient thyroid hormone, T4, which is converted into the more active form, Triiodothyronine (T3), in peripheral tissues.

What is the recommended dosage of Thyrin for adults? 

The initial dose for adults is typically 25-50 mcg/day, with gradual increments every 6-8 weeks based on clinical response and TSH levels.

Can Thyrin be taken during pregnancy? 

Yes, Thyrin is categorized as Pregnancy Category A, but dosage adjustments may be necessary as pregnancy can increase Levothyroxine requirements.

What are the side effects of Thyrin? 

Common side effects include fatigue, weight loss, increased appetite, palpitations, and symptoms of hyperthyroidism like sweating and anxiety.

Are there any drug interactions with Thyrin? 

Yes, concurrent use of certain antidepressants, antidiabetic medications, and digitalis glycosides can affect Thyrin’s efficacy and safety.

How should Thyrin be stored? 

Thyrin should be stored in a cool, dry place below 30°C and protected from light, keeping it out of reach of children.

What should I do in case of a Thyrin overdose? 

In case of overdose, symptoms may include agitation, confusion, and rapid heartbeat. It’s important to seek immediate medical attention.

Can Thyrin affect my heart health? 

Yes, Thyrin can potentially cause cardiac arrhythmias or worsen heart conditions, especially in patients with pre-existing cardiovascular issues.

How often should I monitor my TSH levels while taking Thyrin? 

TSH levels should be monitored regularly to ensure the correct dosage and therapeutic effectiveness, typically every 6-8 weeks after starting treatment.

Is Thyrin suitable for children? 

Yes, Thyrin can be prescribed to children, but the dosage will vary based on age, weight, and specific thyroid conditions.

Can I stop taking Thyrin abruptly? 

No, stopping Thyrin suddenly can lead to withdrawal symptoms and worsen hypothyroidism. Consult your doctor for a proper tapering plan.

What lifestyle changes should I consider while taking Thyrin?

 Maintaining a balanced diet and regular exercise can help manage symptoms of hypothyroidism. Regular check-ups with your doctor are also essential.

Where can I find more information about Thyrin? 

For more information about Thyrin, consult your healthcare provider or visit the product’s official website for detailed guidelines and support.

reference

Company: http://www.squarepharma.com.bd/pdts.php?8940001280075  

USP: https://store.usp.org/product/1365000 

Generic: https://en.wikipedia.org/wiki/Levothyrinine