- Generic name: Metformin Hydrochloride
- Manufacturing Company: Square Pharmaceuticals PLC
Comet Price:
- Per piece: 4.02 Tk
- Strip: Tk 40.20 (10 tablets)
- Box: Tk 420 (10*10 tablets)
Comet 500 mg Tablet is a prescription medication containing Metformin Hydrochloride, a biguanide-type oral antihyperglycemic agent. It is widely used for the treatment of type 2 diabetes mellitus, particularly in overweight patients who are unable to achieve adequate glycemic control through diet and exercise alone. Comet helps lower both basal and postprandial blood glucose levels by decreasing hepatic glucose production, improving insulin sensitivity, and enhancing peripheral glucose uptake. This medication is available for use in adults and children aged 10 years and above and may be used as monotherapy or in combination with insulin or other antidiabetic agents.
Alternatives to Comet:
|
SL: |
Alternative |
Manufacturing |
price |
|
1. |
Comet XR |
Square Pharmaceuticals PLC. |
60.20 Tk |
|
2. |
Metfo XR |
Pacific Pharmaceuticals Ltd. |
70 Tk |
|
3. |
Informer |
Beximco Pharmaceuticals Ltd. |
30 Tk |
|
4. |
Nobesit |
Incepta Pharmaceuticals Ltd. |
60 Tk |
|
5. |
Radimet |
Radiant Pharmaceuticals Ltd. |
40 Tk |
Indications
- Type 2 Diabetes Mellitus: Comet 500 mg is used to manage blood sugar levels in individuals with type 2 diabetes, especially in those who are overweight, when diet and exercise alone are insufficient.
- Monotherapy: It can be prescribed as a stand-alone treatment for type 2 diabetes.
- Combination Therapy: Comet 500 mg may also be used in combination with other oral antidiabetic medications or insulin to achieve better blood sugar control.
- Polycystic Ovary Syndrome (PCOS) (Off-label use): Although not officially approved for this purpose, Comet 500 mg is sometimes prescribed to improve insulin sensitivity in women with PCOS, which may help regulate menstrual cycles and support fertility.
Metformin in Comet 500 mg works by reducing glucose production in the liver, improving insulin sensitivity, and enhancing the uptake of glucose by muscles, which helps lower blood sugar levels effectively.
Pharmacology
Comet 500 contains Metformin, an oral antidiabetic drug from the biguanide class. Its primary mechanism of action involves reducing glucose production in the liver, which helps control blood sugar levels. Additionally, Metformin enhances insulin sensitivity, allowing the body to use insulin more effectively by improving glucose uptake and utilization in the muscles. It also decreases the absorption of glucose in the intestines. Unlike some other antidiabetic medications, Metformin does not cause hypoglycemia, making it a safer option for many patients. Its ability to aid in weight management makes it particularly beneficial for overweight individuals with type 2 diabetes.
Comet’s Dosage and Administration
Adult Dosage (Immediate-Release Tablets):
- Starting dose: 500 mg twice daily or 850 mg once daily, taken with meals.
- Dosage increase: 500 mg weekly or 850 mg every two weeks, up to 2000 mg per day, divided into two or three doses.
- Maximum dose: 2550 mg per day.
Children (Aged 10 and above):
- Starting dose: 500 mg twice daily with meals.
- Dosage increase: 500 mg weekly, up to a maximum of 2000 mg per day, divided into two doses.
Adult Dosage (Extended-Release Tablets):
- Starting dose: 500 mg once daily with the evening meal.
- Dosage increase: 500 mg weekly, up to 2000 mg once daily or 1000 mg twice daily with meals.
- Swallow extended-release tablets whole, do not crush, cut, or chew.
Renal Impairment:
- Do not use in patients with eGFR below 30 mL/min.
- Assess risks if eGFR falls below 45 mL/min.
Comet’s Drug Interactions
Comet (Metformin) can interact with various drugs, affecting its absorption and efficacy. For instance, drugs like Nifedipine may enhance the absorption of Comet, potentially increasing its effects. Additionally, cationic drugs such as Amiloride, Digoxin, and Vancomycin, which are eliminated by renal tubular secretion, may compete with Comet for the same renal transport systems, leading to potential interactions. Certain medications, including diuretics, corticosteroids, estrogens, and thyroid products, may increase blood sugar levels, reducing the effectiveness of Comet in controlling glucose. Therefore, monitoring blood glucose levels is essential when these drugs are used concurrently.
Side effects
Common side effects of Comet (Metformin) include gastrointestinal issues such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite, which often occur at the start of treatment and usually subside over time. Rare side effects may include a reduction in vitamin B12 levels with long-term use, potentially leading to anemia or neuropathy. In very rare cases, serious conditions like lactic acidosis, liver dysfunction, or allergic skin reactions such as erythema and itching may occur. If any severe or persistent side effects arise, medical attention is recommended.
Pregnancy and Lactation
During pregnancy, Comet (Metformin) is generally not recommended as uncontrolled diabetes can increase the risk of congenital abnormalities and perinatal complications. Insulin is usually preferred to maintain blood glucose levels as close to normal as possible during pregnancy.
For lactating mothers, Metformin is excreted into breast milk in small amounts, and although no harmful effects have been observed in breastfed infants, breastfeeding during treatment is not recommended due to limited data on safety. The decision to continue breastfeeding should consider the benefits of breastfeeding and potential risks to the child.
Contraindications
Comet (Metformin) should not be taken in the following cases:
- In case of hypersensitivity to the active ingredient of Comet or other ingredients.
- If you have any type of acute metabolic acidosis (eg lactic acidosis, diabetic ketoacidosis).
- If there is severe renal impairment (GFR <30 mL/min).
- Dehydration, severe infection, shock, etc. Any acute condition that can impair kidney function.
Effects of an overdose of Comet
Overdosage of Comet (Metformin) up to 500 mg has shown no signs of low blood sugar (hypoglycemia). However, taking such high doses can cause lactic acidosis. Lactic acidosis is a serious problem and should be treated in a hospital. Hemodialysis is the most effective way to remove lactic acid and Comet (Metformin) from the body.
Therapeutic Class
Its therapeutic class is: Biguanides
Warning
Here are the warnings for consuming Comet (Metformin) in a shorter format:
- Renal Monitoring: Regular kidney function checks are essential. Contraindicated in patients with eGFR < 30 mL/min.
- Lactic Acidosis Risk: Increased risk, especially in patients with kidney issues or dehydration.
- Vitamin B12 Levels: Long-term use may lower vitamin B12 absorption; annual monitoring is advised.
- Surgery: Discontinue 2-3 days before surgery and only resume after confirming normal kidney function.
- Hypoglycemia Risk: Monitor blood glucose closely when used with insulin or other antidiabetic medications.
- Pregnancy & Lactation: Not recommended during pregnancy; insulin is preferred. Caution advised during breastfeeding.
- Alcohol Use: Avoid alcohol to reduce the risk of lactic acidosis.
Always consult a healthcare professional for guidance.
Chemical Stucture
Chemical Formula: C4H11N5
Chemical Stucture:
Storage Conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
***Special announcement
We have collected the mentioned information from various sources with caution, but they are in no way a substitute for doctors, so consult doctors for any medicine to use. As information is collected from various sources, we cannot guarantee its effectiveness and usefulness. Therefore, we are not responsible for any side effects or adverse effects after taking the medicine due to the information mentioned above.
- This information is for general information only and is in no way a substitute for medical advice.
- Consult your doctor before consuming.
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FAQs on Comet
What is Comet 500 mg used for?
Comet 500 mg is used to treat type 2 diabetes mellitus, especially in overweight individuals, to help manage blood sugar levels.
How does Comet 500 mg work?
Comet 500 mg contains metformin, which works by reducing glucose production in the liver, improving insulin sensitivity, and increasing glucose uptake by cells.
Can I take Comet 500 mg with other diabetes medications?
Yes, Comet 500 mg can be taken with other oral antidiabetic medications or insulin, as prescribed by your doctor.
How should I take Comet 500 mg?
Comet 500 mg should be taken with meals to reduce gastrointestinal side effects. Follow your doctor’s dosage instructions.
What are the common side effects of Comet 500 mg?
Common side effects include nausea, vomiting, diarrhea, stomach pain, and loss of appetite, particularly during the early days of treatment.
Can Comet 500 mg cause hypoglycemia (low blood sugar)?
Comet 500 mg alone typically does not cause hypoglycemia, but it may cause low blood sugar when used with insulin or other diabetes medications.
Is Comet 500 mg safe for children?
Comet 500 mg can be used in children aged 10 years and above for type 2 diabetes, but it should be prescribed by a doctor.
Can I take Comet 500 mg if I am pregnant?
Comet 500 mg is usually not recommended during pregnancy. Insulin is generally preferred to manage blood sugar levels during pregnancy.
Can I drink alcohol while taking Comet 500 mg?
Drinking alcohol while taking Comet 500 mg is not recommended as it may increase the risk of lactic acidosis, a rare but serious side effect.
What should I do if I miss a dose of Comet 500 mg?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Can Comet 500 mg cause vitamin B12 deficiency?
Long-term use of Comet 500 mg can reduce vitamin B12 absorption, so your doctor may monitor your levels and recommend supplements if necessary.
Is Comet 500 mg safe for people with kidney problems?
Comet 500 mg should not be used if you have severe kidney issues. It is important to have your kidney function monitored regularly during treatment.
What happens if I overdose on Comet 500 mg?
Overdosing on Comet 500 mg can lead to lactic acidosis, which is a medical emergency. Seek immediate medical attention if you suspect an overdose.
Can Comet 500 mg be used to treat type 1 diabetes?
No, Comet 500 mg is not used to treat type 1 diabetes. It is only for patients with type 2 diabetes.
Can I stop taking Comet 500 mg if my blood sugar levels are normal?
Do not stop taking Comet 500 mg without consulting your doctor, even if your blood sugar levels are controlled. Stopping the medication may cause your blood sugar to rise again.